|
KMID : 0191120070220010110
|
|
Journal of Korean Medical Science
2007 Volume.22 No. 1 p.110 ~ p.113
|
|
|
Interleukin-1 Beta -511 Polymorphism and Risk of Cervical Cancer
|
|
Kang Sok-Bom
Kim Jae-Won
Park Noh-Hyun
Song Yong-Sang
Park Sang-Yoon
Kang Soon-Beom
Lee Hyo-Pyo
|
|
|
Abstract
|
|
|
|
Cervical cancer is almost invariably associated with infection by human papillomavirus. It is believed that the host genetic factors such as inflammation-induced cytokines may play a role in cervical carcinogenesis. The IL1B gene, encoding IL-1beta cytokine, contains several single nucleotide polymorphisms. One of them which is in the positions -511 (C-T) related with promoter region has been associated with increased IL-1beta production and with increased risk of developing a number of inflammatory diseases and gastric carcinoma. We assessed the association between the IL1B -511 polymorphism and cervical cancer risk in a hospital-based case-control study among 546 Korean women (182 cases; 364 age-matched controls). The allele frequencies of the case subjects (C, 0.42; T, 0.58) were not significantly different from those of control subjects (C, 0.43; T, 0.57). Control subjects were in Hardy-Weinberg equilibrium. The carriers with -511 C/T or T/T genotypes were at higher risk of cervical cancer with odds ratio of 2.42 (95% CI 1.31-4.46, p<0.005). However, there was no difference of cervical cancer risk between C/T heterologous genotypes and T/T homologous genotypes. In conclusion, in Korean population, IL1B -511 C/C genotypes were significantly associated with a decreased risk of cervical cancer.
|
|
|
KEYWORD
|
|
|
Uterine Cervical Neoplasms, Polymorphism, Genetic, Interleukin-1beta, Disease Susceptibility, Case-Control Studies
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|
|